National Defense Medical Center Researchers Provide New Data on Cisplatin Therapy (Ultrasound-Mediated Lysozyme Microbubbles Targeting NOX4 Knockdown Alleviate Cisplatin-Exposed Cochlear Hair Cell Ototoxicity).

Předmět:	HAIR cells LYSOZYMES MEDICAL research personnel MEDICAL centers MICROBUBBLES GENE targeting
Zdroj:	Gene Therapy Weekly; 2024, p1236-1236, 1p
Abstrakt:	A recent report from researchers at the National Defense Medical Center in Taipei, Taiwan, discusses the use of ultrasound-mediated lysozyme microbubbles to target the NOX4 protein and alleviate ototoxicity caused by cisplatin therapy. The study found that the transfection of siNOX4 using lysozyme-shelled microbubbles significantly inhibited the generation of reactive oxygen species (ROS) induced by cisplatin. The researchers concluded that this therapy modality shows promise for future clinical applications in alleviating cisplatin-induced ototoxicity. The full article can be accessed for free at the International Journal of Molecular Sciences website. [Extracted from the article]
Databáze:	Complementary Index
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