| Abstrakt: |
A recent study conducted by a researcher at Widener University in Pennsylvania explores the relationship between obesity and metabolic dysfunction-associated steatotic liver disease (MASLD). The study suggests that MASLD is caused by the storage of free fatty acids in hepatocytes, which are liver cells, due to dysfunctional adipocytes, or fat cells. The progression of the disease is influenced by both biochemical signals and mechanical cues, such as increased liver stiffness. The study highlights the potential therapeutic target of a protein called vimentin, which plays a role in mechanosensing and mechanotransduction. The research aims to contribute to future studies on the mechanobiology of hepatocytes and adipocytes in the context of MASLD and obesity. [Extracted from the article] |
