| Abstrakt: |
A recent study conducted by the Research Foundation for Mental Hygiene in New York City has found that early life adversity (ELA) can lead to heightened threat reactivity and hypervigilance in mice. The study focused on a population of neurons in the lateral central amygdala (CeAL) that express corticotropin releasing factor (CRF), which are believed to play a key role in processing threat and fear. The researchers discovered sex-specific changes in the activity of these neurons following ELA, and inhibiting their function reduced startle responses and threat reactivity. These findings provide insights into the neural circuitry underlying anxiety and fear expression, particularly in relation to early life experiences. [Extracted from the article] |
