| Autor: |
Fedorova, M. S., Gatina, A. E., Ilyina, V. N., Yadykova, L. L., Drukker, V. V., Gorshkova, A. S., Kayumov, A. R., Trizna, E. Y. |
| Předmět: |
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| Zdroj: |
Microbiology (00262617); Aug2024, Vol. 93 Issue 4, p507-510, 4p |
| Abstrakt: |
The bacteriophage Pseudomonas phage Ka1 was isolated from the water of a tributary stream of Lake Baikal, in the area of discharge of treated wastewater of the city of Slyudyanka. The bacteriophage genome contains 46 092 bp and has a 50% G+C pairs (AN OP455935.1). It exhibits 91% identity with the Pseudomonas phage PSA37 genome, belonging to Bruynoghevirus from the class Caudoviricetes suggesting that Ka1 is a new representative of Luz24-like phages (Bruynoghevirus). The bacteriophage lyzes 62% of P. aeruginosa clinical isolates and increases the efficiency of gentamicin, ciprofloxacin, imipenem and meropenem by 4–8-fold against these bacteria. Integrases, transposases and recombinases have not been identified in the genome of the bacteriophage Pseudomonas phage Ka1; which allows using it in the complex therapy of infections caused by P. aeruginosa. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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