Synthesis of novel zwitterionic nido-carborane-containing derivatives of cysteine and methionine.

Autor:	Telegina, A. A., Gruzdev, D. A., Ezhikova, M. A., Kodess, M. I., Ol'shevskaya, V. A., Levit, G. L., Krasnov, V. P.
Předmět:	BORON-neutron capture therapy ZWITTERIONS CYSTEINE BIOACTIVE compounds SULFONIUM compounds ALANINE METHIONINE
Zdroj:	Russian Chemical Bulletin; Jun2024, Vol. 73 Issue 6, p1716-1724, 9p
Abstrakt:	Alkylation of 9-methylthio-nido-carborane under the action of the corresponding iodo derivatives of alanine and homoalanine furnished new (nido-carboran-9-yl) derivatives of (R)-cysteine and (S)-methionine. The synthesized chiral nido-carborane derivatives contain asymmetric carbon and sulfur atoms, as well as a chiral plane. The developed approach to the synthesis of sulfur-containing B(9)-substituted nido-carborane derivatives can be used in the preparation of bioactive compounds, including potential boron delivery agents for boron neutron capture therapy of oncological diseases. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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