Azetidine and cyclopropylamine in the "1,2,4-triazine" methodology for the synthesis of α-functionalized 2,2′-bipyridines.

Autor: Shtaitz, Ya. K., Valieva, M. I., Ladin, E. D., Rammohan, A., Krasnoperova, K. D., Belyaev, N. A., Kopchuk, D. S., Zyryanov, G. V., Rusinov, V. L.
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Zdroj: Russian Chemical Bulletin; Jun2024, Vol. 73 Issue 6, p1681-1685, 5p
Abstrakt: Functionalization of 3-(2-pyridyl)-1,2,4-triazines with small (aza)cyclic compounds (azetidine and cyclopropylamine) via nucleophilic ipso-substitution of the cyano group and subsequent transformation of the 1,2,4-triazine ring into pyridine one via the aza-Diels—Alder reaction were explored. The successful proceeding of such a transformation depended on the structure of the nucleophilic residue: both steps were successfully implemented upon using a cyclopropylamine derivative, while in the case of azetidine-containing 1,2,4-triazines, there was only the resinification of the reaction mass. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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