| Autor: |
Coles, Lawrence, Ventrella, Domenico, Carnicer-Lombarte, Alejandro, Elmi, Alberto, Troughton, Joe G., Mariello, Massimo, El Hadwe, Salim, Woodington, Ben J., Bacci, Maria L., Malliaras, George G., Barone, Damiano G., Proctor, Christopher M. |
| Předmět: |
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| Zdroj: |
Nature Communications; 7/26/2024, Vol. 15 Issue 1, p1-11, 11p |
| Abstrakt: |
Electrocorticography is an established neural interfacing technique wherein an array of electrodes enables large-area recording from the cortical surface. Electrocorticography is commonly used for seizure mapping however the implantation of large-area electrocorticography arrays is a highly invasive procedure, requiring a craniotomy larger than the implant area to place the device. In this work, flexible thin-film electrode arrays are combined with concepts from soft robotics, to realize a large-area electrocorticography device that can change shape via integrated fluidic actuators. We show that the 32-electrode device can be packaged using origami-inspired folding into a compressed state and implanted through a small burr-hole craniotomy, then expanded on the surface of the brain for large-area cortical coverage. The implantation, expansion, and recording functionality of the device is confirmed in-vitro and in porcine in-vivo models. The integration of shape actuation into neural implants provides a clinically viable pathway to realize large-area neural interfaces via minimally invasive surgical techniques. Large area electrocorticography is limited by invasive craniotomies. Here, the authors combine soft robotic bioelectronics with origami inspired packaging to create a minimally invasive electrocorticography array. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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