| Abstrakt: |
COVID-19 is one of the major pandemic diseases caused by SARS-CoV-2. Vaccination is one of the methods used that reduce the spread of an infectious disease. Consequently, we aimed to measure liver parameters (alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), total serum bilirubin (TSB), and lactate dehydrogenase (LDH) and albumin), as well as bone markers (Calcium, phosphorous, parathyroid hormone (PTH) with thyroid stimulating hormone (TSH) as marker for the severity of the disease in non-vaccinated and vaccinated SARS-COV-2 patients. Between November 2021 and May 2022, 130 samples of both genders (healthy and infected with COVID-19) were obtained and divided into three groups: Healthy individuals (50), vaccinated (30) and non-vaccinated (50) group” (ages; 20–65). The findings of the current study showed that ALT, ALP, and LDH significantly elevated (P < 0.01), and despite comparing patients who were not vaccinated to those who were, albumin considerably dropped. Moreover, AST and TSB moderately elevated in unvaccinated group in comparison to unvaccinated patients. Calcium and phosphorous slightly decreased in non-vaccinated and vaccinated patients as compare to control. Whereas PTH and TSH significantly less in both patient groups than in control. “The optimal cutoff values for parameters were determined by ROC curve analysis. In conclusion, vaccine plays a major role in minimizing liver biomarkers in COVID-19 patients. Moreover, low concentrations of bone markers were associated with both vaccinated and nonvaccinated COVID-19 patients. Therefore, the bone health status of COVID-19 patients and liver markers are helpful for the diagnosis and monitoring of disease severity in COVID‐19 patient. [ABSTRACT FROM AUTHOR] |
