Supplementary Material for: Bioactivation of Cinnamic Alcohol in a Reconstructed Human Epidermis Model and Evaluation of Sensitizing Potency of the Identified Metabolites.

Autor: Ndreu, Lorena, Carlsson, Josefine, Ponting, David J., Niklasson, Ida B., Stéen, E. Johanna L., McHugh, Lukas, O'Boyle, Niamh M., Luthman, Kristina, Karlberg, Ann-Therese, Karlsson, Isabella
Předmět:
Zdroj: Frontiers in Toxicology; 2024, p1-19, 19p
Abstrakt: This document is supplementary material for a study conducted by researchers from Sweden and Ireland. It includes tables and figures related to the analysis of metabolites in a reconstructed human epidermis model. The findings suggest the presence of various metabolites and provide information on their detection and quantification. The document also discusses the identification and characterization of glutathione adducts formed with certain compounds. Results from a murine local lymph node assay indicate that these compounds have varying degrees of sensitization potency. External sources are referenced for further information on spectral prediction and skin sensitization. [Extracted from the article]
Databáze: Complementary Index