Impact of qualifying artery on the efficacy of stenting plus medical therapy versus medical therapy alone in patients with symptomatic intracranial stenosis: a post- hoc analysis of the CASSISS trial.
Autor: | Qiaowei Wu, Jie Wang, Bingjie Zheng, Jingtao Qi, Shancai Xu, Pei Wu, Guang Zhang, Zhiyong Ji, Chunlei Wang, Jinbiao Yao, Liqun Jiao, Peng Gao, Tao Wang, Daming Wang, Tianxiao Li, Yingkun He, Zhenwei Zhao, Yiling Cai, Wei Wu, Weiwen He |
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Předmět: |
DATA analysis
BASILAR artery STENOSIS SEX distribution LOGISTIC regression analysis CEREBRAL arterial diseases SURGICAL stents TREATMENT effectiveness MULTIVARIATE analysis DESCRIPTIVE statistics CAROTID artery stenosis CEREBRAL arteries VERTEBRAL artery COMBINED modality therapy STATISTICS ISCHEMIC stroke CONFIDENCE intervals CEREBRAL arteriosclerosis |
Zdroj: | Journal of NeuroInterventional Surgery; Jul2024, Vol. 16 Issue 7, p663-669, 7p |
Abstrakt: | Background A recent trial failed to show any benefit of stenting plus medical therapy over medical therapy alone in patients with symptomatic intracranial stenosis. We aimed to examine whether the symptomatic qualifying artery modifies the effect of stenting plus medical therapy. Methods This is a post-hoc analysis of the CASSISS trial that included patients with symptomatic intracranial stenosis, randomly assigned to undergo stenting plus medical therapy or medical therapy alone; 358/380 patients were included. Multivariable logistic regression analysis was used with an interaction term to estimate the altered treatment effect by the qualifying artery. The primary outcome was a composite of stroke or death within 30 days or stroke in the qualifying artery territory beyond 30 days through 1 year. The five secondary outcomes included stroke or death related to the qualifying artery territory at 2 and 3 years. Results No significant treatment allocation-bystenosis site interaction was observed (P |
Databáze: | Complementary Index |
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