An integrated view of cisplatin-induced nephrotoxicity, hepatotoxicity, and cardiotoxicity: characteristics, common molecular mechanisms, and current clinical management.

Autor: Oliveira, Caroline Assunção, Mercês, Érika Azenathe Barros, Portela, Fernanda Santos, Malheiro, Lara Fabiana Luz, Silva, Henrique Bruno Lopes, De Benedictis, Laís Mafra, De Benedictis, Júlia Mafra, Silva, Clara Cotta d'Ávilla e, Santos, Alberto Christian Luz, Rosa, Dã Pinheiro, Velozo, Helloisa Souza, de Jesus Soares, Telma, de Brito Amaral, Liliany Souza
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Zdroj: Clinical & Experimental Nephrology; Aug2024, Vol. 28 Issue 8, p711-727, 17p
Abstrakt: Cisplatin (CP) is a chemotherapy drug widely prescribed to treat various neoplasms. Although fundamental for the therapeutic action of the drug, its cytotoxic mechanisms trigger adverse effects in several tissues, such as the kidney, liver, and heart, which limit its clinical use. In this sense, studies point to an essential role of damage to nuclear and mitochondrial DNA associated with oxidative stress, inflammation, and apoptosis in the pathophysiology of tissue injuries. Due to the limitation of effective preventive and therapeutic measures against CP-induced toxicity, new strategies with potential cytoprotective effects have been studied. Therefore, this article is timely in reviewing the characteristics and main molecular mechanisms common to renal, hepatic, and cardiac toxicity previously described, in addition to addressing the main validated strategies for the current management of these adverse events in clinical practice. We also handle the main promising antioxidant substances recently presented in the literature to encourage the development of new research that consolidates their potential preventive and therapeutic effects against CP-induced cytotoxicity. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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