| Autor: |
Schinnerl, Dagmar, Riebler, Marion, Schumich, Angela, Haslinger, Sabrina, Bramböck, Alice, Inthal, Andrea, Nykiel, Marek, Maurer-Granofszky, Margarita, Haas, Oskar A., Pötschger, Ulrike, Köhrer, Stefan, Nebral, Karin, Dworzak, Michael N., Attarbaschi, Andishe, Strehl, Sabine |
| Předmět: |
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| Zdroj: |
Blood Cancer Journal; 7/22/2024, Vol. 14 Issue 1, p1-5, 5p |
| Abstrakt: |
This article presents a study on the prognosis and risk factors associated with DUX4 B-cell acute lymphoblastic leukemia (B-ALL). The researchers analyzed genetic alterations and clinical characteristics in a cohort of DUX4 B-ALL patients. They found that certain genetic alterations, such as the IKZF1plus deletion profile and TP53 mutation, were associated with a worse prognosis. Additionally, they observed that the response to therapy, as measured by measurable residual disease (MRD), differed in DUX4 B-ALL compared to other subtypes. The authors suggest that further research is needed to refine risk stratification and optimize therapy for DUX4 B-ALL patients. [Extracted from the article] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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