Chrysophanol inhibits of colorectal cancer cell motility and energy metabolism by targeting the KITENIN/ErbB4 oncogenic complex.

Autor: Varlı, Mücahit, Kim, Eunae, Oh, Songjin, Pulat, Sultan, Zhou, Rui, Gamage, Chathurika D. B., Gökalsın, Barış, Sesal, Nüzhet Cenk, Kim, Kyung Keun, Paik, Man-Jeong, Kim, Hangun
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Zdroj: Cancer Cell International; 7/19/2024, Vol. 24 Issue 1, p1-17, 17p
Abstrakt: Background: Expression of the KITENIN/ErbB4 oncogenic complex is associated with metastasis of colorectal cancer to distant organs and lymph nodes and is linked with poor prognosis and poor survival. Methods: Here, we used in vitro and in silico methods to test the ability of chrysophanol, a molecule of natural origin, to suppress the progression of colorectal cancer by targeting the KITENIN/ErbB4 complex. Results: Chrysophanol binds to ErbB4, disrupting the ErbB4/KITENIN complex and causing autophagic degradation of KITENIN. We demonstrated that chrysophanol binds to ErbB4 according to a molecular docking model. Chrysophanol reversed KITENIN-mediated effects on cell motility, aerobic glycolysis, and expression of downstream effector genes. Moreover, under conditions of KITENIN overexpression, chrysophanol suppressed the production of onco-metabolites. Conclusion: Chrysophanol suppresses oncogenic activities by targeting the KITENIN/ErbB4 complex. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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