| Abstrakt: |
A recent report from the University of Chicago highlights research on adrenal cortex hormones and their role in trained immunity. Trained immunity refers to the epigenetic and metabolic reprogramming of the immune system in response to specific stimuli, resulting in increased cytokine and effector responses to pathogens. The researchers conducted a high-throughput screen of 2,000 drugs and drug-like compounds and identified over two dozen small molecules that induce a training phenotype in the absence of initial immune activation. Surprisingly, glucocorticoids, traditionally considered immunosuppressive, were found to be among the top candidates. This research expands our understanding of innate immune memory and offers new avenues for studying and applying trained immunity. [Extracted from the article] |
