| Abstrakt: |
A recent study conducted by researchers at Universite Paris Cite in France has shed light on the development of cutaneous squamous cell carcinoma (SCC) in patients with recessive dystrophic epidermolysis bullosa (RDEB), a rare hereditary skin disease. The study found that RDEB patients with high-risk primary SCC had a higher neutrophil-to-lymphocyte ratio in the tumor microenvironment and an increased proportion of neutrophil extracellular traps (NETs). Additionally, the presence of citrullinated histone H3, a marker of NETs, in the serum of RDEB patients with high-risk primary SCC was associated with an unfavorable prognosis. These findings suggest that citrullinated histone H3 may serve as a potential blood marker for predicting prognosis in RDEB-SCCs. [Extracted from the article] |
