| Abstrakt: |
A study conducted at Sidi Mohamed Ben Abdellah University in Fez, Morocco, aimed to improve the solubility of the drug Albendazole using a mixture design approach. The researchers tested the use of nonionic surfactants and phospholipids to enhance water solubility. The experiments showed a significant improvement in solubility, up to 90%, compared to Albendazole in water without excipients. The study concluded that the solubility of Albendazole is affected by the combination of tween(R) 80, Solutol(R) HS 15, and Lipoid(R) S75. Run 3, which contained specific percentages of these components, showed the highest improvement in solubility and had an average particle size of 11nm. [Extracted from the article] |
