| Autor: |
Primahana, Gian, Lotulung, Puspa Dewi Narrij, Ernawati, Teni, Kurniasih, Ida Rahmi, Sundowo, Andini, Artanti, Nina, Hanafi, Muhammad |
| Předmět: |
|
| Zdroj: |
AIP Conference Proceedings; 2024, Vol. 3027 Issue 1, p1-6, 6p |
| Abstrakt: |
Cinchona alkaloids (quinine, cinchonine and cinchonidine) cinnamate ester (1-3) were successfully synthesized and characterized by using liquid chromatography-mass spectrometry and nuclear magnetic resonance spectroscopy. The cytotoxicity on MCF-7 breast cancer cell lines as well as in-silico properties of absorption, metabolism, excretion and druglikeness (ADME) properties were evaluated. Cinchona alkaloid cinnamate ester compounds exhibited cytotoxic activity against MCF-7 breast cancer cell lines with minimum inhibitory concentration ranging from 4.26 to 0.21 µM. The strongest cytotoxic activity was shown by compound 3 (cinchonine cinnamate ester) with an IC50 value of 0.21 µM. In-silico calculation of ADME properties showed that all compounds satisfied the Lipinski rule of five and showed no carcinogenicity effect on rats or mice. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
