Structural insights into the triple agonism at GLP-1R, GIPR and GCGR manifested by retatrutide.

Autor: Li, Wenzhuo, Zhou, Qingtong, Cong, Zhaotong, Yuan, Qingning, Li, Wenxin, Zhao, Fenghui, Xu, H. Eric, Zhao, Li-Hua, Yang, Dehua, Wang, Ming-Wei
Předmět:
Zdroj: Cell Discovery; 7/17/2024, Vol. 10 Issue 1, p1-4, 4p
Abstrakt: This article explores the potential of retatrutide as a treatment for type 2 diabetes and obesity. Retatrutide is a triple agonist that activates three receptors involved in glucose metabolism. It has shown promising results in obesity treatment, with greater weight loss compared to other medications. Phase 2 trials have also demonstrated significant improvements in glycemic control and weight reduction in individuals with type 2 diabetes. The article provides structural insights into the interactions between retatrutide and the receptors, which could inform further development and clinical trials. [Extracted from the article]
Databáze: Complementary Index