| Autor: |
BUKIA, T., GAGELIDZE, N., TABATADZE, T., BUSKANDZE, L., KHAZALIA, S., GOLETIANI, A. |
| Předmět: |
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| Zdroj: |
Oxidation Communications; 2024, Vol. 47 Issue 1, p48-58, 11p |
| Abstrakt: |
The synthesis of new compounds for the treatment of infectious diseases remains one of the challenging tasks of the modern world. The prime focus of this research is to take action on amantadine-based derivatives synthesised by multicomponent Ugi reaction. Ugi reaction is widely used in the synthesis of biologically active compounds. It is an efficient and useful method of synthesis to prepare different types of bonds and compounds, such as peptide-like compounds, different natural products, heterocyclic derivatives, and low molecular drug-like compounds. Ugi reaction includes four compounds: acids, aldehyde or ketone, amine, and isonitrile. Adamantane is considered an interesting field of research due to its exceptional qualities. Adamantane derivatives are actively used in pharmaceutical industry due to their durable properties. Its derivatives are powerful compounds in a wide range of applications from systemic to topical therapy. In this study, some new amantadine (1-amino adamantane) moiety-containing compounds were synthesised via multicomponent Ugi reaction by using amanatadine, ethyl isocyanoacetate, some aldehydes, and carboxylic acids and corresponding dipeptide-like derivatives were isolated. The structure of the synthesised compounds was established by IR, NMR and LC-MS measurements. Synthesised compounds were studied for their antimicrobial activity against 10 different bacterial species using disk diffusion methods. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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