A solvent controlled regioselective synthesis of 2- and 4-substituted α-carbolines under palladium catalysis.

Autor: Chatterjee, Sarat, Khatun, Rousunara, Ali, Mahammad, Chowdhury, Chinmay
Předmět:
Zdroj: Chemical Communications; 7/25/2024, Vol. 60 Issue 58, p7427-7430, 4p
Abstrakt: A facile method for the chemodivergent synthesis of α-carbolines 1via palladium catalyzed [3+3] annulations of tosyliminoindolines 6 with α, β-unsaturated aldehydes 7 is described. Mechanistically, this cascade reaction proceeds through either a carba-Michael (in DMF) or aza-Michael (in NMA) pathway followed by intramolecular cyclization of the intermediate. A preliminary photo-physical study on selected products is also reported. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index