| Autor: |
Jovan, Kulić, Kristina, Drašković Mališ, Milena, Dubravac Tanasković, Milan, Kulić, Bojan, Joksimović, Nikolina, Elez-Burnjaković |
| Předmět: |
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| Zdroj: |
Genetics & Applications; 2024 Special Issue, p40-40, 1p |
| Abstrakt: |
The outbreak of COVID-19 caused by SARS-CoV-2 has led to a global health crisis, highlighting the urgent need for understanding the factors influencing disease susceptibility and severity. Among the various genetic factors under investigation, the angiotensin I converting enzyme (ACE) insertion/deletion (I/D) polymorphism has garnered significant attention due to its potential association with COVID-19. ACE, a key component of the renin-angiotensin system (RAS), plays a crucial role in regulating blood pressure and fluid balance. The ACE gene I/D polymorphism has been implicated in various cardiovascular and respiratory diseases due to its influence on ACE levels and activity. In our study, we aimed to investigate connection between ACE gene I/D polymorphism with asymptomatic and symptomatic COVID-19 patients. The study featured two groups, asymptomatic and symptomatic COVID-19 patients, each with 100 subjects. DNA was extracted, PCR-amplified, and analyzed by gel electrophoresis. Results revealed a statistically significant association (p=0.050) between examined groups in the frequency of the II genotype. Significantly, higher number of asymptomatic COVID-19 patients (25%) had II genotype when compared to the patients with COVID-19 symptoms (14%). However, no statistical significance was observed for the DD and ID genotypes. Interestingly, the D allele was significantly (p=0.039) more often present in group with COVID-19 symptoms (64%) when compared to the asymptomatic group (54.5%). Notably, no statistical significance was found for the I allele. Presented results confirmed the significant relationship between ACE (I/D) polymorphism, specifically the D allele and risk of COVID-19 symptomatic disease. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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