| Autor: |
Emina, Mrđanović, Merima, Smajlhodžić-Deljo, Adna, Softić, Amra, Džuho, Neven, Meseldžić, Almir, Badnjević, Tamer, Bego, Lejla, Gurbeta Pokvić, Adna, Ašić |
| Předmět: |
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| Zdroj: |
Genetics & Applications; 2024 Special Issue, p35-35, 1p |
| Abstrakt: |
The combined model of testing the athletes encompasses the assessment of basic motor skills, psychological stress testing, and genetic testing, whereby genetic predisposition is important for determining the athletes’ predisposition for specific disciplines and risk of sports-related injuries. The insertion/deletion (I/D) allele of the angiotensin-converting enzyme gene (ACE) (rs1799752) is one of the most studied polymorphisms, with the I allele linked to enhanced performance in runners and rowers and generally in disciplines requiring endurance, while the D allele is associated with sports requiring strength and power. The ACTN3 (alpha-actinin-3) rs1815739 polymorphism is linked to athletic performance, with the 577R allele associated with lower risk of training-related injuries and a better response to intensive exercises and training process, while the 577X variant is found in fewer athletes and is associated with increased likelihood of injuries due to intensive training process, thus requiring additional caution. We are hereby presenting the first results of genetic testing of 32 young Alpine skiers over these two genetic polymorphisms. DNA isolation from whole blood samples was done using the PureLink™ Genomic DNA Mini kit, followed by amplification of target polymorphisms using real-time PCR with TaqMan SNP assays. Regarding ACTN3 genotypes, 58.1% of successfully analyzed participants were C/C homozygotes (577RR), 32.3% were T/C heterozygotes (577RX), and 9.7% were T/T homozygotes (577XX). The results were inconclusive for one participant. Regarding ACE testing, 25 participants were successfully genotyped and none of them carried Alu sequence (i.e., all participants were D/D homozygotes). The results of genetic testing could serve as valuable guidance for optimizing training based on the obtained results, potentially reducing the frequency of athletes’ injuries. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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