| Autor: |
Pimentel de Morais, Catarina, Branco, Pedro, Pereira, André, Castelhano, Luís, Donato, Mariana, Correia, Filipe, O'Neill, Assunção, Santos, Ricardo, Escada, Pedro |
| Zdroj: |
Laryngoscope; Aug2024, Vol. 134 Issue 8, p3458-3465, 8p |
| Abstrakt: |
Objective: Cochlear implant surgery is guided by principles of atraumatic insertion as to protect the inner ear. Previous studies suggest the potential benefit of steroids in patients undergoing cochlear implantation (CI), although the optimal route of administration has yet to be determined. We aim to systematically review the human studies of hearing and vestibular function preservation in patients undergoing CI receiving perioperative steroids and to discuss their role. Data Sources: Search performed in PubMed, EMBASE, and CENTRAL databases in December 2023. Review Methods: Studies comparing several methods of steroid delivery and conventional management for patients undergoing CI were identified. Primary outcomes included hearing and vestibular function preservation. Secondary outcomes included reported adverse events, routes of steroid administration, and the presence of a control group without steroid administration. Results: A total of 15 studies (N = 659) met inclusion criteria. Methodology, doses, route of steroid administration, and follow‐up duration differed between most studies. Audiometric, vestibular, and hearing preservation (HP) results were inconsistent. In 12 studies, perioperative steroids were associated with either increased HP or vestibular function preservation. Only two studies reported adverse events related to oral corticosteroid therapy. Conclusions: There is a tendency for perioperative steroids to have a positive impact, at least in the short term, on hearing and vestibular function preservation in CI. Topical corticosteroid therapy appears to have a superior risk–benefit profile. There is a need for future carefully designed randomized controlled trials to determine the ideal route of steroid administration and its real impact in the long term. Laryngoscope, 134:3458–3465, 2024 [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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