Antimicrobial Activity of Positively Charged Oligopeptides with Theoretical High α-Helix Content against Cutibacterium acnes.

Autor: Yoshida, Miyako, Hayashi, Saki, Haraguchi, Tamami, Ito, Momoka, Hatanaka, Yoshiro, Yoshii, Miki, Tatsuoka, Hiroaki, Tanaka, Shigemitsu, Nagao, Toshihiro
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Zdroj: International Journal of Molecular Sciences; Jul2024, Vol. 25 Issue 13, p7445, 8p
Abstrakt: Cutibacterium acnes is abundant and commonly exists as a superficial bacteria on human skin. Recently, the resistance of C. acnes to antimicrobial agents has become a serious concern, necessitating the development of alternative pharmaceutical products with antimicrobial activity against C. acnes. To address this need, we evaluated the antimicrobial activity of CKR-13—a mutant oligopeptide of FK-13 with increased net charge and theoretical α-helical content—against C. acnes in modified Gifu Anaerobic Medium broth by determining the minimum inhibitory concentration (MIC). CKR-13 exerted greater antimicrobial activity against C. acnes than FK-13 in the broth at pH 7.0. The antimicrobial activity of CKR-13 with RXM against C. albicans was pH-dependent. The ionization of CKR-13 and pH-dependent growth delay of C. albicans was suggested to be associated with the increase in CKR-13 antimicrobial activity. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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