| Autor: |
Tsalouchidou, Panagiota-Eleni, Müller, Hans-Helge, Mintziras, Ioannis, Strehlau, Sascha, Hahn, Wiebke, Belke, Marcus, Zahnert, Felix, Kräling, Gunter, Menzler, Katja, Knake, Susanne |
| Předmět: |
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| Zdroj: |
Neurological Research & Practice; 7/11/2024, Vol. 6 Issue 1, p1-7, 7p |
| Abstrakt: |
Objective: This study investigates the association of Body Mass Index (BMI) and age of epilepsy onset, in patients with epilepsy associated with temporal encephaloceles (TEs). Methods: A comprehensive PubMed literature review was conducted using the keywords "temporal encephaloceles" and "epilepsy" for identifying articles for the analysis. Inclusion criteria encompassed all evidence levels reporting patients with TE-related epilepsy and documented BMI. Logistic regression analyses were performed to examine the effect of BMI on predicting epilepsy onset after the 25th year of age. Spearman's correlation assessed the relationship between BMI with epilepsy onset. Finally, the association between BMI and postsurgical outcomes, distinguishing between more favourable outcomes (Engel Class I and II) and less favourable outcomes (Engell Class III and IV) was explored. Results: Of the initially identified 88 articles, nine were included in the analysis, involving 127 patients with TE-related epilepsy and reported BMI. The mean age of epilepsy onset was 24.9 years (SD = 14.8 years), with a mean BMI of 28.0 kg/m2 (SD = 7.4 kg/m2). A significant positive correlation was observed between BMI and age of epilepsy onset (rho = 0.448, p < 0.001). Female patients had higher BMI compared to male patients (30.1 kg/m2, SD = 8.7 kg/m2 and 26.5 kg/m2, SD = 5.3 kg/m2 respectively, p = 0.008). However, the epilepsy onset did not differ significantly between male and female patients (p = 0.26). The bivariate logistic regression showed that patients with increased BMI were more likely to have an epilepsy onset after the 25th year of age, adjusted for the confounder sex (OR = 1.133, 95%-CI [1.060, 1.211], p < 0.001). Finally, a potential trend indicated a higher average BMI among patients with more favourable postsurgical outcomes than less favourable postsurgical outcomes (27.3 kg/m2, SD = 7.7 kg/m2 and 24.8 kg/m2, SD = 2.2 kg/m2 respectively, p = 0.076). Significance: The occurrence of TEs has already been associated with increased BMI and idiopathic intracranial hypertension. The current analysis indicates a significant correlation between elevated BMI and delayed epilepsy onset in cases of TE-related epilepsy. This finding suggests the presence of unique underlying pathomechanisms among epilepsy patients with higher BMI and TEs, supporting the hypothesis of a potential gradual influence of BMI on TE formation. Consequently, this may lead to a milder, more gradual progression of epileptogenesis compared to individuals with a normal BMI. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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