Electrochemical synthesis of phosphorylated azaspiro[4.5]di/trienones through dearomative spirocyclization.

Autor:	Zhou, Xiaocong, Wang, Jian, Ma, Dumei, Shen, Yirui, Zhao, Yufen, Wu, Ju
Předmět:	BIOCHEMICAL substrates HIGH temperatures OXIDIZING agents RING formation (Chemistry) CATIONS
Zdroj:	Chemical Communications; 7/21/2024, Vol. 60 Issue 57, p7351-7354, 4p
Abstrakt:	Cp2Fe-mediated electrochemical synthesis of a diverse array of phosphorylated azaspiro[4.5]di/trienones has been developed, which demonstrated broad substrate scope and good diastereoselectivity. It represents the first example of electrochemical synthesis of phosphorylated azaspiro[4.5]di/trienones, circumventing the need for external oxidants and high temperatures. Moreover, a plausible mechanism including radical-initiated dearomative cyclization driven by ferrocenium cations has been provided, which was supported by the related mechanistic study. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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