Assiut University Researchers Have Provided New Study Findings on Ulcers (The role of nuclear factor kappa beta signaling in the therapeutic effect of tadalafil against dexamethasone-induced gastric ulcer in rats).

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Zdroj: Drug Week; 7/19/2024, p274-274, 1p
Abstrakt: A recent study conducted by researchers at Assiut University in Egypt explored the efficacy of tadalafil and dexlansoprazole in treating stomach ulcers caused by dexamethasone in male albino Wister rats. The study found that treatment with either tadalafil or dexlansoprazole alone significantly reduced ulcer index, pepsin activity, tumor necrosis factor-a, and malondialdehyde levels, while increasing mucin content, prostaglandin E2, and nitric oxide levels. When tadalafil and dexlansoprazole were administered together, there was a more notable decrease in ulcer index and other factors, suggesting that the combination has promising therapeutic potential in preventing stomach ulcers caused by dexamethasone. Further research is needed to explore these findings. [Extracted from the article]
Databáze: Complementary Index