Researchers from University of Gdansk Detail New Studies and Findings in the Area of Herpesvirus (The Herpesvirus Ul49.5 Protein Hijacks a Cellular C- Degron Pathway To Drive Tap Transporter Degradation).

Předmět:	RESEARCH personnel PROTEINS UBIQUITIN ligases PEPTIDES LIGASES
Zdroj:	Genomics & Genetics Weekly; 7/19/2024, p1509-1509, 1p
Abstrakt:	Researchers from the University of Gdansk in Poland have conducted a study on the Herpesvirus and its interaction with the transporter associated with antigen processing (TAP). The study found that the UL49.5 gene product of the Herpesvirus binds to TAP, inhibiting peptide transport and triggering its degradation. The researchers identified CLR2KLHDC3 as the E3 ligase responsible for the degradation of TAP. This research provides new insights into the mechanisms of immune evasion by viruses. [Extracted from the article]
Databáze:	Complementary Index
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