| Abstrakt: |
Researchers from Huazhong University of Science and Technology in Wuhan, China have conducted a study on the role of N7-methylguanosine (m7G) modification in Alzheimer's disease (AD). They analyzed gene expression data from 667 AD samples and 503 control samples to identify AD subtypes based on m7G regulator genes. They found two distinct subgroups, with cluster A representing a high-risk subgroup for AD. The differentially expressed genes in cluster A were enriched in immune and synapse-related pathways, suggesting their contribution to AD progression. The researchers also identified five feature genes associated with AD and validated their diagnostic performance. This study provides new insights into the role of m7G modification, the immune microenvironment, and potential therapeutic targets for AD. [Extracted from the article] |
