| Autor: |
Compaore, Tegwinde Rebeca, Sawadogo, Isidore, Traore, Lassina, Ouattara, Abdoul Karim, Soubeiga, Serge Theophile, Zida, Sylvie, Kanfon, Richard, Sanou, Vera, Soulama, Issiaka, Kambire, Dinanibe, Yonli, Albert Theophane, Ouedraogo, Oumarou, Dabire, Charlemagne, Nikiema, Abdoul Rahamani, Zoure, Abdou Azaque, Lougue, Siaka, Sagna, Tani, Zongo, Dramane, Djigma, Wendkuuni Florencia, Ouedraogo, Henri Gautier |
| Předmět: |
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| Zdroj: |
Journal of Experimental & Molecular Biology; 2024, Vol. 25 Issue 2, p101-111, 11p |
| Abstrakt: |
The ACE2 gene polymorphisms (rs143936283, rs146676783, and rs4646116) in infected and noninfected persons by SARS-CoV-2 in Burkina Faso. Our cross-sectional study population comprised 137 SARS-CoV-2 infected persons and 181 non-infected persons. Three ACE2 gene polymorphisms, rs143936283, rs146676783, and rs4646116, were genotyped using the realtime PCR standard TaqMan allelic discrimination technique. The association between SARSCoV-2 infection and the polymorphisms were evaluated by a binary logistic regression. There was no association between the polymorphisms rs143936283 rs4646116 haplotypes, and SARS-CoV-2 infection in our study population. However, in the female population, the heterozygous genotype CT of rs146676783 increased by two and half the risk (OR=2.58 95%CI (1.2-5.48), p= 0.014) of being infected by SARS-CoV-2. Additionally, carrying the homozygous minor allele (genotype TT) of rs146676783 increased by more than five and half the risk (OR=5.57 95%CI (1.64-18.78), p=0.006) of being infected by SARS-CoV-2 among females. This study showed that the ACE2 gene variant rs146676783 was associated with an increased risk of being infected by SARS-CoV-2 in females, suggesting a need for further investigation to contribute to a better understanding of the African COVID-19 enigma. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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