| Autor: |
Lai, Peng, Wang, Li, Deng, Chenjie, Xu, Yixin, Ma, Xiao-Yan, Cheng, Chun-Ru, Huang, Sheng-Xiong |
| Předmět: |
|
| Zdroj: |
Natural Product Research; Jul2024, Vol. 38 Issue 14, p2498-2504, 7p |
| Abstrakt: |
Two new prenylxanthone derivatives, asperidulins A (1) and B (2), along with a known emodin analogue (3) were isolated from an apple-derived fungus Aspergillus nidulans KIB-HACM-01. Their structures were elucidated by interpretation of HRMS, NMR, and comparisons of specific optical rotation. Asperidulin B (2) exhibited a moderate cytotoxicity against A549 and BEAS-2B with an IC50 values of 13.62 ± 0.41 and 11.27 ± 0.52 μM, and methyl-averantin (3) showed moderate cytotoxicities against all six tested cell lines (HL-60, A549, SMMC-7721, MDA-MB-231, SW480, BEAS-2B) with IC50 values ranging from 8.93 ± 0.56 to 35.27 ± 0.25 μM. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
