Immunotherapeutic effects of specific and nonspecific mRNA‐lipid nanoparticles in a mouse model of HDM‐induced airway inflammation.

Autor:	Thanasarnthungcharoen, Chanatip, Chanasit, Supapich, Fievez, Laurence, Kaewamatawong, Theerayuth, Patniboon, Piyachat, Lin, Paulo J. C., Bureau, Fabrice, Jacquet, Alain
Předmět:	LABORATORY mice AIRWAY resistance (Respiration) ANIMAL disease models IMMUNOGLOBULIN E PEPTIDE vaccines NANOPARTICLES INFLAMMATION
Zdroj:	Allergy; Jul2024, Vol. 79 Issue 7, p1974-1978, 5p
Abstrakt:	This article discusses the immunotherapeutic effects of specific and nonspecific mRNA-lipid nanoparticles (LNPs) in a mouse model of house dust mite (HDM)-induced airway inflammation. The study found that the mRNA-LNP vaccines were able to reduce key allergic parameters such as IL-5, specific IgE, and eosinophilia. However, the mRNA-LNP vaccines also switched HDM-specific airway eosinophilia into airway neutrophilia. The authors speculate that this may be due to the development of allergen-specific Th17 cells induced by the mRNA-LNP vaccines. Further research is needed to understand the distinct immunological pathways mediated by HDM-specific and nonspecific mRNA-LNP vaccines. [Extracted from the article]
Databáze:	Complementary Index
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