| Autor: |
Lysenko, Vladimir, Kuznietsova, Halyna, Dziubenko, Nataliia, Byelinska, Iryna, Zaderko, Alexander, Lysenko, Tetiana, Skryshevsky, Valeriy |
| Zdroj: |
BioNanoScience; Jun2024, Vol. 14 Issue 2, p1819-1831, 13p |
| Abstrakt: |
Carbon dots (CDs) are sub-10 nm carbon particles with notable photoluminescence and photoelectrochemical properties, finding diverse applications in optoelectronics, chemistry, and medicine. Their unique physicochemical properties give rise to antimicrobial actions, being realized through complex mechanisms. Discovering the latter was the aim of this review. The primary interaction of CDs with negatively charged bacterial cells is ensured by electrostatic interaction with that because of CDs' surface positive charge. Hydrophobic forces further contribute to this interaction. Modification of CDs with different alkyl chains enhances their antibacterial effect by balancing positive charge and hydrophobicity, facilitating membrane penetration and causing damage to bacterial cells. Another powerful antibacterial mechanism is the ability of photoexcited CDs to generate reactive oxygen species under visible light, effectively destroying critical biomolecules and inducing cell death. Additionally, the photothermal conversion properties of CDs, allowing them to raise local temperatures upon near-infrared light excitation, result in DNA damage and protein denaturation within bacteria, forming the basis for photothermal therapy. Following infiltration of bacterial walls and membranes, CDs can bind to DNA and RNA in bacteria and fungi through noncovalent interactions, inducing structural changes in DNA and affecting RNA. These multifaceted mechanisms underscore the potential of CDs as versatile antibacterial agents with applications across various biomedical fields. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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