| Autor: |
MITSUHISA NISHIMOTO, KAZUTOSHI FUJITA, ARITOSHI RI, SAIZO FUJIMOTO, YASUO OGUMA, SHINGO TOYODA, MAMORU HASHIMOTO, TAKASHI KIKUCHI, SHOGO ADOMI, YOSHITAKA SAITO, YASUNORI MORI, TAKAFUMI MINAMI, MASAHIRO NOZAWA, KAZUHIRO YOSHIMURA, MAKOTO HOSONO, HIROTSUGU UEMURA |
| Předmět: |
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| Zdroj: |
Cancer Diagnosis & Prognosis; Jul/Aug2024, Vol. 4 Issue 4, p441-446, 6p |
| Abstrakt: |
Background/Aim: Radium-223 treatment reduces the risk of death in patients with metastatic castration-resistant prostate cancer (CRPC). This study analyzed the prognostic factors in patients treated with radium-223 dichloride. Patients and Methods: Patients who received radium-223 dichloride were retrospectively analyzed. Prostate-specific antigen (PSA) response and alkaline phosphatase (ALP) decline rates were analyzed. Overall survival (OS) was evaluated using Kaplan– Meier curves, and prognostic factors for OS were assessed using Cox proportional hazards analysis. Results: Fifty-six patients were included in the study. The five-year OS rate in patients after diagnosis of CRPC was 62.2% [95% confidence interval (CI)=27.55-112.45], while the five-year OS rate in patients at the initiation of radium-223 treatment was 21.3% (95%CI=17.20-36.79). Six patients (11.1%) had a >50% PSA decline rate, and 10 (17.9%) had a >50% ALP decline rate. Cox proportional hazards analysis showed that PSA levels at the initiation of radium-223 treatment [hazard ratio (HR)=1.00; 95%CI=1.00-1.00; p=0.0054] and Gleason Pattern (GP) 5 (HR=5.42; 95%CI=1.08-27.27; p=0.0400) were associated with OS. Patients with GP 5 had a significantly poorer prognosis compared with patients with a GP ≤4. Early administration of radium-223 as a first- or second-line treatment was not associated with OS compared with late administration of radium-223 as a third-line or later treatment. Conclusion: GP 5 and high PSA levels at radium-223 initiation were associated with worse OS. Radium-223 as first- or second-line treatment was not associated with OS. Therefore, a treatment strategy for CRPC based on GP 5 is needed. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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