The use of ibuprofen as an anti-seizure medication: a systematic review.
| Autor: | Tristan, Ariel, Wijayahadi, Noor, Kristina, Tri Nur, Jaeri, Santoso |
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| Předmět: |
EPILEPSY prevention
BIOLOGICAL models DISEASE duration INTRAPERITONEAL injections NEURONS ELECTROENCEPHALOGRAPHY BRAIN NEUROINFLAMMATION SYSTEMATIC reviews MEDLINE MICE SEIZURES (Medicine) ANIMAL experimentation PROSTAGLANDINS IBUPROFEN ONLINE information services FEBRILE seizures CYTOKINES ANTICONVULSANTS DISEASE progression PHARMACODYNAMICS |
| Zdroj: | Journal of Epileptology; May2024, Vol. 32 Issue 1, p3-8, 6p |
| Abstrakt: | Background. Epileptic seizure is a transient period of signs and symptoms resulting from the abnormal excessive and synchronous neuronal activity in the brain, resulting in brain damage. To prevent complications, the antiseizure medication is needed. Several agents have a potency of anti-seizure effect, including ibuprofen. Unfortunately, there are few studies regarding the anti-seizure effect of ibuprofen. Aim. To determine the anti-seizure effect of ibuprofen to reduce the symptoms of epileptic seizures. Materials and Methods. A systematic review using the databases ScienceDirect, SpringerLink, Nature, and Pubmed. The article was obtained using the keywords “ibuprofen” and (“epilepsy” or “anticonvulsant” or “antiseizure” or “epileptic” or “neuroinflammation”) in the period 2012 to 2022 and screened with inclusion and exclusion criteria. Out of the 1376 articles screened, there are three studies included in this review. The SYRCLE Risk of Bias Tool was used to assess the risk of bias, and the data was synthesised using SWiM guidelines. Results. Ibuprofen affects seizures by reducing the number, grade, and duration of seizure intensity in the PTZ-induced rats. Despite the risk of bias assessment revealing some potential bias in the studies, our study shows that ibuprofen has potency as an additional agent for epileptic seizures among febrile convulsive patients. Conclusion. In animal models of seizures, ibuprofen has an antiseizure effect by reducing the number, grade, and duration of seizures [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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