| Autor: |
Doncheva, Nina, Mihaylova, Anita, Zlatanova, Hristina, Ivanovska, Mariya, Delev, Delian, Kostadinov, Ilia |
| Předmět: |
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| Zdroj: |
Pharmacia (0428-0296); 2024, Vol. 71 Issue 1, p1-9, 9p |
| Abstrakt: |
The study aimed to investigate anti-inflammatory and immunomodulatory effects of cholecalciferol (vitamin D3 ) in rats with complete Freund's adjuvant-induced arthritis (AIA) and lipopolysaccharide (LPS)-induced inflammation. In the first experiment, rats were treated with cholecalciferol 14 days before or from the day of induction of arthritis. In the second set-up, animals received cholecalciferol for 14 days which was followed by LPS injection. TNF (tumour necrosis factor)-alpha, IL (interleukin)-1β, TGF (transforming growth factor)-β1 levels were measured by enzyme linked immunosorbent assay (ELISA). Cholecalciferol treatment reduced paw oedema and ankle joint diameter in AIA. Significantly lower IL-1β concentrations were found in cholecalciferol-treated arthritic rats. In LPS-challenged rats, cholecalciferol markedly lowered serum TNF-α, whereas an elevation in IL-1β concentrations was observed. Cholecalciferol slightly increased TGF-β1 serum concentration in arthritic rats and non-significantly reduced its level in LPS-challenged animals. Our findings showed that cholecalciferol exerts immunomodulatory properties which probably contribute to its anti-inflammatory effect. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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