| Autor: |
Hawkins, Sara J., Gärtner, Yvonne, Offner, Thomas, Weiss, Lukas, Maiello, Guido, Hassenklöver, Thomas, Manzini, Ivan |
| Předmět: |
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| Zdroj: |
European Journal of Neuroscience; Jul2024, Vol. 60 Issue 1, p3719-3741, 23p |
| Abstrakt: |
Across vertebrate species, the olfactory epithelium (OE) exhibits the uncommon feature of lifelong neuronal turnover. Epithelial stem cells give rise to new neurons that can adequately replace dying olfactory receptor neurons (ORNs) during developmental and adult phases and after lesions. To relay olfactory information from the environment to the brain, the axons of the renewed ORNs must reconnect with the olfactory bulb (OB). In Xenopus laevis larvae, we have previously shown that this process occurs between 3 and 7 weeks after olfactory nerve (ON) transection. In the present study, we show that after 7 weeks of recovery from ON transection, two functionally and spatially distinct glomerular clusters are reformed in the OB, akin to those found in non‐transected larvae. We also show that the same odourant response tuning profiles observed in the OB of non‐transected larvae are again present after 7 weeks of recovery. Next, we show that characteristic odour‐guided behaviour disappears after ON transection but recovers after 7–9 weeks of recovery. Together, our findings demonstrate that the olfactory system of larval X. laevis regenerates with high accuracy after ON transection, leading to the recovery of odour‐guided behaviour. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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