| Autor: |
Kabelitz, Dieter, Cierna, Lea, Juraske, Claudia, Zarobkiewicz, Michal, Schamel, Wolfgang W., Peters, Christian |
| Předmět: |
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| Zdroj: |
European Journal of Immunology; Jul2024, Vol. 54 Issue 7, p1-9, 9p |
| Abstrakt: |
Vitamin C (ascorbic acid) is a potent antioxidant and a cofactor for various enzymes including histone demethylases and methylcytosine dioxygenases. Vitamin C also exerts direct cytotoxicity toward selected tumor cells including colorectal carcinoma. Moreover, vitamin C has been shown to impact immune cell differentiation at various levels including maturation and/or functionality of T cells and their progenitors, dendritic cells, B cells, and NK cells. γδ T cells have recently attracted great interest as effector cells for cell‐based cancer immunotherapy, due to their HLA‐independent recognition of a large variety of tumor cells. While γδ T cells can thus be also applied as an allogeneic off‐the‐shelf product, it is obvious that the effector function of γδ T cells needs to be optimized to ensure the best possible clinical efficacy. Here we review the immunomodulatory mechanisms of vitamin C with a special focus on how vitamin C enhances the effector function of γδ T cells. We also discuss future directions of how vitamin C can be used in the clinical setting to boost the efficacy of adoptive cell therapies. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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