IgA multiple myeloma-associated mediastinal spinal plasmacytoma presenting as spinal cord compression.

Autor: Prathivadhi-Bhayankaram, Sruti, Marar, Rosalyn, Atiya, Samir, Krishnan, Mridula
Zdroj: BMJ Case Reports; Jun2024, Vol. 17 Issue 6, p1-3, 3p
Abstrakt: Multiple myeloma associated with extramedullary plasmacytoma at initial presentation is rare. We describe a case of a man in his 30s who initially presented with symptoms of spinal cord compression. Further imaging revealed a mediastinal tumour, with a biopsy confirming plasmacytoma. Immunofixation revealed IgA lambda paraprotein. Bone marrow biopsy demonstrated atypical T-cell cytotoxic proliferation and trilineage hypoplasia. The patient was diagnosed with extramedullary plasmacytoma with active IgA multiple myeloma. The patient received mediastinal radiation to the tumour, followed by anti-myeloma therapy. This diagnosis is critical as managing a solitary plasmacytoma drastically differs from an extramedullary plasmacytoma with active multiple myeloma. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index