EXPLORING THE NEXUS OF SUBCLINICAL ATHEROSCLEROSIS AND SYNDECAN-4 LEVELS IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS.
| Autor: | Yümer, Aslı, Kadıyoran, Cengiz, Çizmecioğlu, Ahmet, Küçük, Adem |
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| Předmět: |
ATHEROSCLEROSIS risk factors
RISK assessment MEDICAL information storage & retrieval systems CROSS-sectional method BODY mass index STATISTICAL significance DATA analysis ENZYME-linked immunosorbent assay SYSTEMIC lupus erythematosus GLYCOPROTEINS DESCRIPTIVE statistics CHI-squared test IN vivo studies LONGITUDINAL method CAROTID intima-media thickness CASE-control method MEDICAL records STATISTICS CLINICS RHEUMATOLOGY CONFIDENCE intervals DATA analysis software BIOMARKERS CAROTID artery ultrasonography REGRESSION analysis |
| Zdroj: | Rheumatology Quarterly; Jun2024, Vol. 2 Issue 2, p80-88, 9p |
| Abstrakt: | Aim: Systemic lupus erythematosus (SLE) is a persistent inflammatory autoimmune disorder. In an endeavor to juxtapose disease activity against the acknowledged occurrence of subclinical atherosclerosis in patients with SLE, this study sought to evaluate the interrelation between carotid intima-media thickness (CIMT), SLE disease activity index (SLEDAI), and Syndecan-4 (SDC4) levels. Material and Methods: This study assembled a cohort comprising 70 patients with SLE aged 18 years and older, devoid of concomitant systemic diseases, was assembled, alongside a control group consisting of 68 healthy volunteers attending the rheumatology outpatient clinic. The assessment quantifying SDC4 levels using enzyme-linked immunosorbent assay method. CIMT measurements were conducted for both the patient and control groups. SLEDAI scores, as well as sociodemographic and laboratory data for both groups, were systematically extracted from the hospital's digitalized medical records system. Results: SDC4 levels within the patient cohort (8.211±9.069) exhibited a statistically significant reduction compared to the SDC4 levels in the control group (26.221±24.653). Furthermore, the CIMT values for the patient group (0.558±0.116) demonstrated a statistically significant variance in contrast to the CIMT values of the control group (0.49±0.117). Remarkably, a noteworthy correlation emerged between SDC4 and CIMT. Additionally, a significant association was identified between SDC4 levels and body mass index (p<0.05). Further correlations were discerned between SDC4 levels and SLEDAI in the patient group. Correspondingly, a statistically significant correlation was observed between CIMT and SLEDAI in the patient group. Conclusion: Despite the statistically significant elevation in CIMT, an essential indicator of subclinical atherosclerosis, within our patient group compared with the control group, we posit that SDC4 levels may not be reliable predictors of atherosclerosis. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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