| Autor: |
Krishnan, Jithin, Muraleedharan, C. V., Sasi, Renjith, Joseph, Roy |
| Předmět: |
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| Zdroj: |
Analytical & Bioanalytical Electrochemistry; Jun2024, Vol. 16 Issue 6, p614-627, 14p |
| Abstrakt: |
Deep brain stimulation (DBS) is a surgical procedure that involves implanting a medical device to send electrical signals to specific brain areas to improve movement disorder symptoms. There are many efforts to introduce closed-loop-based stimulation in DBS therapy, but most are in the experimental stages. The current study is the characterization of a hybrid electrode for closed-loop control of the DBS adaptive stimulations. The electrode is fabricated as an interdigitated woven model and accommodates current steering stimulation and a sensing mechanism to provide input for the adaptive close loop system. The study incorporates the identification of damaging effects of stimulation, estimation of safe charge injection limits which eliminate tissue damage, and estimation of safe charge injection limits to minimise electrode damage through electrochemical analyses, including Cyclic Voltammetry, Electrochemical Impedance spectroscopy, and Chronopotentiometry. The study also addresses the development of an appropriate electrical equivalent model that could be employed in later analytical studies. The study has derived that for an electrode (ø1.3mm×1.5mm) to safeguard against physiological mass action-induced damage, the maximum permissible charge injection per phase during stimulation should be set to Qma=2.08 µC, corresponding to a charge density of 33.98 µC/cm2. In the case of the Pt-10Ir electrode (ø1.3mm×1.5mm), the safe charge injection threshold to prevent damage from electrochemical reactions is established at 4.1 µC (at a rate of 67 µC/cm2), surpassing Shannon's tissue-damaging limit of 2.08 µC (at 33.98 µC/cm2). [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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