The Correlation between Cytokines Imbalance and Vitamin D level in Patients with Early Chronic Obstructive Pulmonary Disease (COPD) and the role of Vitamin D in Pulmonary Disease.

Autor:	Shaheen, Saima, Humayun, Anjum, Zaib, Jahangir, Ali Bukhari, Syed Muhammad Sajid, Jadoon, Madeeha, Sammar, Kinza
Předmět:	THERAPEUTIC use of vitamin D PHOTOTHERAPY STATISTICAL correlation PEARSON correlation (Statistics) VITAL capacity (Respiration) DATA analysis ENZYME-linked immunosorbent assay TREATMENT effectiveness DESCRIPTIVE statistics LONGITUDINAL method INTERFERONS OBSTRUCTIVE lung diseases RESEARCH STATISTICS FORCED expiratory volume CYTOKINES DATA analysis software VITAMIN D BIOMARKERS TUMOR necrosis factors INTERLEUKINS
Zdroj:	Pakistan Journal of Chest Medicine; 2023, Vol. 29 Issue 2, p148-154, 7p
Abstrakt:	Background: Vitamin D, recognized for its dual role as an immune regulator and essential nutrient crucial for human well-being, exerts a multifaceted impact on the intricate immune processes found in individuals suffering from Chronic Obstructive Pulmonary Disease (COPD). In addition to its established functions in maintaining phosphate-calcium balance and bone mineralization, it exerts both direct and indirect effects on cellular elements within the COPD environment, thereby influencing the levels of inflammatory factors in the airways. Objective: The study sought to ascertain the role of sunlight and vitamin D in lung disease, as well as the relationship between vitamin D levels and cytokine discord in patients in early stage chronic obstructive pulmonary disease (COPD). Methodology: A prospective study was conducted at Ponch Medical College, Rawalakot between January 2020 to December 2020 and comprised of 120 patients. COPD pulmonary function (LF) I & COPD LF II patients were divided into two groups (n = 60 each). An immunosorbent assay that uses enzymes was used to measure the blood levels inflammatory TNF-α, IFN-γ, interleukin 4 (IL-4), and IL-6 in order to identify the Th1/Th2 marker. A proportion of IFN-γ to IL-4 was also a part of the treatment. Results: Between the LF I alongside LF II groups, there was a significant difference (p < 0.04) in FEV1pred%, FEV1 or IFN-γ, IL-4, F, IFN-γ/IL-4, and IL-6. In patients with early-stage COPD, cytokines (Th1/Th2) were significant correlated with forced volume percent (FEV1pred%) (r < 0.485, p < 0.002) and compelled exhalation volume/forced lifespan (FEV1/FVC) (r = 0.254, p = 0.015). Conclusion: Mostly cases with early-stage COPD had a vitamin D deficiency. Together with the FEV1/FVC LF parameters, it showed a positive correlation. This research offers experimental evidence in favour of vitamin D's role in COPD prevention and treatment, as well as possible anti-inflammatory action mechanisms. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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