| Autor: |
Imtiaz, Humaira, Hayat, Nida Qasim, Shaheen, Sadaf, Shaheen, Robina, Hussain, Atif, Jadoon, Sara |
| Předmět: |
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| Zdroj: |
Pakistan Journal of Chest Medicine; 2023, Vol. 29 Issue 1, p76-82, 7p |
| Abstrakt: |
Background: Individuals with COVID-19 may experience respiratory collapse due to severe bilateral pneumonia. Because there was a substantial threat of infections during biopsies, histological samples are rare. Objective: The present study aimed to assess the histomorphological alterations in the lungs affected by COVID-19 using a CT scan and lung ultrasonography. Methodology: We conducted a prospective observational study on individuals who had severe COVID-19. Twelve exploration zones were created from the thorax to link lung ultrasonography (LU) and CT-scan findings. Each block was split into 7 cuts of 2.5µm thick sections. Specimens for Histology were stained with Weigert-Van-Giesson (to evaluate elastic fiber architecture) and Masson's trichrome eosine and hematoxylin, (for collagen deposition and fibrosis). SPSS 20 was used for the analysis of the data. Results: The patients' mean age was 61.65 ± 12.57 years, with 96% of them being male. A total of 179 thoracic areas were examined in 25 individuals who underwent evaluation using both thoracic LU and chest CT scans. B2-lines were the most common LU finding (49.7%). Ground-glass opacity (GGO), was the most common CT-scan result (31.3%). Findings from a pathological CT scan were frequently seen when B2-lines or C-lines were found using LU (positive predictive value, PPV, 85.1%). Diffuse alveolar damage (DAD) accounted for 75% of the histological samples, while persistent interstitial inflammation (25%). Conclusion: Lung Ultrasonography (LU) frequently reveals B2-lines and C-profiles in patients experiencing severe COVID-19 and respiratory impairment. These findings often correspond to various CT patterns and histological outcomes such as Diffuse Alveolar Damage (DAD) and lung fibrosis. LU holds potential in predicting prognosis, assessing response to therapy, and optimizing the necessity for CT scans. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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