Predictive value of neutrophil-to-lymphocyte ratio in coronary chronic total occlusion patients.

Autor:	Qian LI, Yue YU, Ya-Qiong ZHOU, Yi ZHAO, Jin WU, Yuan-Jing WU, Bin DU, Pei-Jian WANG, Tao ZHENG
Předmět:	NEUTROPHIL lymphocyte ratio RISK assessment MYOCARDIAL infarction DATA analysis RESEARCH funding CORONARY occlusion MAJOR adverse cardiovascular events EVALUATION of medical care CARDIOVASCULAR diseases risk factors SEVERITY of illness index CHI-squared test CHRONIC diseases KAPLAN-Meier estimator ONE-way analysis of variance STATISTICS CONFIDENCE intervals DATA analysis software BIOMARKERS C-reactive protein DISEASE risk factors
Zdroj:	Journal of Geriatric Cardiology; May2024, Vol. 21 Issue 5, p542-549, 8p
Abstrakt:	BACKGROUND The neutrophil to lymphocyte ratio (NLR) has been reported as a novel predictor for atherosclerosis and cardiovascular outcomes. This study aimed to determine the effects of NLR on long-term clinical outcomes of chronic total occlusion (CTO) patients. METHODS A total of 670 patients with CTO who met the inclusion criteria were included at the end of the follow-up period. Patients were divided into tertiles according to their baseline NLR levels at admission: low (n = 223), intermediate (n = 223), and high (n = 224). The incidence of major adverse cardiac events (MACEs) during the follow-up period, including all-cause death, nonfatal myocardial infarction (MI), or ischemia-driven revascularization, were compared among the three groups. RESULTS Major adverse cardiac events were observed in 27 patients (12.1%) in the low tertile, 40 (17.9%) in the intermediate tertile, and 61 (27.2%) in the high NLR tertile (P < 0.001). Kaplan-Meier analysis demonstrated a significantly higher incidence of MACE, ischemia-driven coronary revascularization, non-fatal MI, and mortality in patients within the high tertile than those in the low and intermediate groups (all P < 0.001). Multivariable COX regression analysis showed that the high tertile of baseline NLR level showed a strong association with the risk of MACE (hazard ratio [HR] = 2.21; 95% confidence interval [CI]: 1.21–4.03; P = 0.009), ischemia-driven coronary revascularization (HR = 3.19; 95% CI: 1.56–6.52; P = 0.001), MI (HR = 2.61; 95% CI: 1.35–5.03; P = 0.043) and mortality (HR = 3.78; 95% CI: 1.65–8.77; P = 0.001). CONCLUSION Our findings suggest that NLR is an inexpensive and readily available biomarker that can independently predict cardiovascular risk in patients with CTO. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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