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| Zdroj: |
Gastroenterology Week; 7/8/2024, p1666-1666, 1p |
| Abstrakt: |
A recent study conducted by the University of Hawai'i Cancer Center explored the role of TBX3 in intrahepatic cholangiocarcinoma (iCCA), a primary liver malignancy with limited treatment options. The researchers found that overexpression of TBX3 inhibited the growth of iCCA cells and reduced cholangiocarcinogenesis in a mouse model. They also discovered that TBX3 binds to the MAD2L1 promoter, and knockdown of MAD2L1 reduced the growth of iCCA models. The study suggests that overexpression of TBX3 suppresses the progression of cholangiocarcinoma by repressing MAD2L1 expression. [Extracted from the article] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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