| Abstrakt: |
A recent study conducted by researchers at the National and Kapodistrian University of Athens has explored the potential of N-hydroxypyridinedione (HPD) compounds as inhibitors of the Hepatitis B virus (HBV) RNase H enzyme. The researchers designed and synthesized 18 novel HPD oximes, as well as other related compounds, and found that all of them effectively inhibited viral replication in cell assays. These compounds exhibited low cytotoxicity and high selectivity indexes, making them promising candidates for the development of potent anti-HBV agents. This research contributes to the understanding of the structure-activity relationships of HPD compounds and their potential as therapeutic agents for HBV. [Extracted from the article] |
