| Abstrakt: |
A systematic review conducted by researchers at the University of St. Joseph in Beirut, Lebanon, explores the genomic alterations associated with KRAS wild-type pancreatic adenocarcinoma, a particularly aggressive form of cancer. The review aims to summarize these alterations, their potential targeted treatments, and their impact on disease progression. The researchers identified several targetable genomic alterations, including BRAF, EGFR, FGFR, MSI-H/dMMR, Her2/ERBB2 amplification, BRCA1/2 and other HRDs, and gene fusions like ALK, NTRK, and NRG1. This research provides valuable insights into potential treatment options for KRAS wild-type pancreatic adenocarcinoma. [Extracted from the article] |
