Wroclaw Medical University Researchers Broaden Understanding of Psoriasis (In Vitro and In Vivo Antipsoriatic Efficacy of Protected and Unprotected Sugar-Zinc Phthalocyanine Conjugates).

Předmět:	MEDICAL research personnel PSORIASIS SIGNAL peptides ADALIMUMAB SKIN diseases REPORTERS & reporting
Zdroj:	Drug Week; 7/12/2024, p3621-3621, 1p
Abstrakt:	New research conducted by Wroclaw Medical University in Poland explores the potential use of zinc phthalocyanine (ZnPc) and its sugar conjugates as antipsoriatic agents. The study found that a protected glucose-ZnPc conjugate demonstrated superior phototoxicity compared to other conjugates and free ZnPc. In vivo photodynamic therapy (PDT) using the glucose-ZnPc conjugate showed significant improvement in Psoriasis Area and Severity Index (PASI) and restored normal skin morphology. These findings suggest that sugar-conjugated zinc phthalocyanines could be potential candidates for targeted PDT in psoriasis treatment, warranting further clinical investigations. [Extracted from the article]
Databáze:	Complementary Index
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