| Abstrakt: |
A new study conducted by researchers at the Instituto de Tecnologia Quimica e Biologica Antonio Xavier in Portugal explores the use of biodegradable poly(octamethylene suberate) nanoparticles (POS-NPs) for the treatment of skin diseases and conditions. The study investigates the encapsulation of four therapeutic molecules (caffeine, quercetin, hydrocortisone, and adapalene) within the POS-NPs and examines their physicochemical properties, cytotoxicity, and permeation rates. The researchers found that while hydrocortisone and caffeine-loaded nanoparticles were not suitable for dermal applications at the explored drug concentrations, adapalene showed a high permeation rate and no toxic impact on reconstructed human epidermis. This research provides valuable insights into the design and biocompatibility of biodegradable nanoparticles for the treatment of skin disorders. [Extracted from the article] |
