| Abstrakt: |
Researchers from the National Institute of Pharmaceutical Education and Research (NIPER) in India have developed a new class of antibacterial agents to combat Staphylococcus aureus infections. The researchers designed and synthesized 1,4-benzothiazine-based bisamide derivatives that target bacterial peptide deformylase (PDF). Molecular modeling showed that these derivatives had better docking scores compared to the natural product actinonin. Two derivatives were found to have promising antibacterial activity in vitro, and one of them, compound 8bE, was able to inhibit S. aureus biofilm formation on urinary catheters. The study suggests that these synthesized molecules could have potential applications in treating S. aureus infections and preventing biofilm formation on medical devices. [Extracted from the article] |
